VOLUME 3, NO4, DEC 1981
 
Dissymetries and Radii of Gyrations of Cellulose Acetate by Light Sctattering Techniques

S NOOR ,M KALEEM ,N AHMAD ,

A wide range of concentration (1.0 x 104 to 6.0 x 10-2 g/rnl) of cellulose acetate in acetone is considered and dissymetry of all these concentrations is measured at different angles from 450 to 900 at intervals of SO degree. These dissymetries are measured by using two wave lengths ( 436 nm. and 546 nm. ) of incident light. An equation is derived for the dependence of dissymetry upon angle of measurement, considering the system as coil-like molecules. Making use of this equation and Zimm plot method, the radii of gyration of these solutions are measured. It is concluded that one gets the same results by both the methods. It is further concluded that the radius of gyration increases as the concentration decreases. 
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A Facile Route to (beta)- Carbolines

N WAHEED ,A U RAHMAN ,

N-imidotIyptamines may be converted to the corresponding p.carbolines is high yields by treatment with NaBH4-HCL.
Pages(167)
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Effects of Inorganic Sa1ts on the Copolymerization of Vinyl and alkyl Monomers Part-II Copolymerization of Styrene and Acrylonitrile in the Presence of some Inorganic Sa1ts

A R KHAN ,S A K LODHI ,

The thermal copolymerization of styrene and acrylonitrile in the presence of inorganic salts like SJCl2, CdCl2, MnCl2 and NiCI2 Was invesdpted. The dereuing effects of thele salts on the rate was observed. The initiation reaction takes place thermally by the adsorption of the reacting monomers on the solid lUIface of inoIpDic: salts. The addition of salt doemot appreciably change the reactivity ratio values of the monomer. The lo'wering of molecular weight suggests that salts behave as a chain transfer agents.
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Spectrophotometric, Solvent Extraction and Chelate Formation Study of Divalent Iron with Triazine in Presence of Large Exceues of Trivalent Iron

I ARAIN ,M H MEMON ,I H HASHMI ,

A comparative study of 4 substituted derivatives of symmetrical and ummetrical triazines as chromogenic reagents of the ferroin type has established 3-(2-pyridyl}-S, 64ip­henyl-l,2,4-triazine (PDn, as a highly sensitive and selective reagent for divalent iron PleseDt in association with large amount of iron (1lI). The ease with which the lUghly colowed metal ions can be extracted into immilCible solvent to give stable solution, makes this reagent useful for the determina­tion of traces of ln (U) present in a mixture L f lron(ll) and Iron(llI).
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Determination of Trace Amount of Iron (II) in the Presence of Iron (III) using Extraction Formation Method

M H MEMON ,I H HASHMI ,I ARAIN ,

The suitability of 3-(2-Pyridyl)-S,6-(diphenyl>-l,2,4-triazine (PDT) as a reagent for determination of iron (II) in presenoe of iron (III) is evaluated. The studies were made of the tris (pDT)-iron (II) complex formed in strong acid solution and its extraction in chloroform and also in l,l,l-trichloroethane. This serves as a useful method for the determination of microgram quantities of iron !II) in 'presenoe of iron (III).
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The Analytical use of Tetrahydroxy-p-benzoquinone for the Determination and Estimation of Cations

G H KAZI ,N A NAQVI ,M MAHMOOD ,Z H SHAH ,

Tetrahydroxy-p-benzoquinone (I) has been reported to react with large number of metal ions and has been used in estimations as metal indicator of precipitant. However, due to its non­selective nature and various colour reactions over a wide range of pH, the use of (I) in analytical sepa­ration has not been investigated in past. The work reported here has been carried out to explore the possibility of use of (I) in quantitative analysis of metals by grmmetric,spectropbotornetric. titrimet­tic and atomic absorption methods. The experimental findings have also been employed in analysis of synthetic mixtures of cations so as to establish correltion of reactions between metals and reagent (D.
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Synthesis of 2-substituted phenyl-3-aryloxyacetyl hydrazono methylenyl-indoles as Central Nervous System Active Agents

S S TIWARI ,S MISRA ,R AGARWAL ,R K SATSANGI ,

2-Aryl -dol -3-a1dehydes were condensed with aryloxyacetyl hydrazines under nor­mal condition of 'azomethine' formation, to obtain twelve of the title compounds. The structures of these compounds have been confumed by elemental analysis and the I.R. spectra. The compounds are non-toxic, eNS depressants and hypothermic on albino mice.
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Chemistry and CNS activity of 1-(4-methyl-coumarin-7yl).oxyacetyl-3.methyl-4-(substituted phenyl hydrazono/azo )-pyrazolin.5-ones

R AGARWAL ,R K SATSANGI ,S S TIWARI ,

Twelve title compounds (IVa-I) were synthesised by two different methods. The iust method involved the reaction of 4-methyl-7-coumarin-oxyacetyl hydrazine (0 and corresponding, ethyl-2)-<Uoxo butyi'at -2-aryl hydrazones (11), while the second method involved the diazo-coupling of l-{4-methyl-coumarin-7yl)-oxyacetyl-3-methyl-pyrazolin-S-one (UI) with different substituted phenyl diazonium chlorides. The structures of 1-(4-methyl·-coumarin-7yl)-oxyacety1-3-methyl-4­(substituted phenyl hydrazono/azo)-pyrazolin-S-ones (IVa-I) have been assigned on the basis of IR and PMR spectroscopy. The obtained data indicate that these compounds exist in hydrazone form instead of tautomeric keto-azo or enol-azo forms. The compounds are relatively non-toxic except one and are eNS stimulants.
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Synthesis of 2-Styryl-3, 6,8-Trisubstituted Quinazolin-4(3H)-ones as Anti-inflammatory Agents

C SINGH ,V S MISRA ,R AGARWAL ,K C CHAUDHARY ,

Sixteen new quinazolinone derivatives have been synthesiled by the reaction of 2­styryl-6, 8-disubstituted benzoxazjn.4-o~ with two different aromatic ambles (p-morpholino lIDiline and 2-aminopyridjne) or with two different hydruiclea (viz. iJonicotink: acid hydrazide and 2,4­dinitrophenyl acetic acid hydrazide) in pyridine. The intermediate 2-styryl 6.lktiIubstituted benzo. xin-4-ones, were prepared by the reaction of cinnlmQyl chloride and 6.8-cliIUbstituted anthranlic acid in dry pyridine. Some of the synthesiled title compounds have been found to poaeIS lipificant anti-inflammatory activity against carrageenin-induced in1Iammation. An attempt hu also been made to establish a definite structure activity relationship. Further, in addition, the compounds were found to be mild central nervous system depreuaats and were quite non toxic. The structures of the un­known compounds were confirmed by elemental and spectral (LIt. cl P.M.L) analysis.
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Possible Antifertility Compounds - Part III: Synthesis of 2-Hippuryl-3-Aryl-Quinazolinones

S S TIWARI ,R K SATSANGI ,A UPRETI ,

A number of 2-Hippyry1-3-aryl-quinazolinones were synthesDed by the co~densa­tion of 2-Hippyryl-3, l(4H)-benzoxainone and various aromatic amines: No signitlcant antifertility activity in male mts was observed with any of them.
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