VOLUME 9, NO4, DEC 1987
123
 
COMPLEXES OF Fe(III), Co(II) AND Zn(II) WITH THIOCARBAMYLDITHIOCARBAMATE AND THEIR ANTIBACTERIAL ACTIVITY

NASIR AHMAD ,S. TANSNIM HASSAN ,CHRISTY MUNIR ,

A number of coordination compounds of a new ligand thiocarbamyldi-thiocarbamate (TCDTC) with Fe3+, Co2+, Cu2+, and Zn2+ ions have been synthesized. The ligand is unstable and cannot be isolated from its reaction mixture, however it readily forms air stable complexes with these metals. These compounds have been characterized by elemental analysis, conductance measurements, absorption and infra-red spectra studies. The compounds (Fe(tcdtc)2Cl.H2O], [Co(tcdtc)2 (H2O)2]H2O and [Cu(tcdtc)2 (H2O)2] have an octahedral structure with tcdtc coordinating through its S1, S3 atoms forming six membered chelates. The complex [Zn(tcdtc)2] H2O has tetrahedral arrangement of ligands around the metal atom. The complexes [Co(tcdtc)2. (H2O)2]H2O and [Cu(tcdtc)2(H2O)2] show antibacterial activity against B. subtilis, V. Cholrea and E. coli wile [Fe(tcdtc)2Cl.H2O] shows very little activity against E. coli and B. subtilis.
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PREPARATION OF NEW BENZIMIDAZOLES AS POTENTIAL THERAPEUTIC AGENTS-IV

FARZANA MALIK ,ZAHIDA MAQBOOL ,MARIA C. GARCIA ALVAREZ ,MASHOODA HASAN ,

Preparation, physical properties, chromatographic behaviour, mass-spectral fragmentation pattern and 1H n.m.r. spectra of 4-(2-benzimidazolyl)-4-methyl pentanoic acid (3a) and 1,3-bis (2-benzimidazolyl)-2,2-dimethyl propane (4) are described.
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THE PFEIFFER EFFECT STUDIES IN SOME MIXED LIGAND COMPLEXES OF COBALT (III)

CHRISTY MUNIR ,EARNEST OBED JOHN ,NASIR AHMAD ,

The Pfeiffer effect is studied in a series of thirteen coordination compounds of cobalt (III) of type [Co(AA)3]n+ and [Co(AA)2 BB]n+ where AA and BB are 1,10-phenanthroline, 2,2'-bipyridyl, oxalate or corbonate ions, cis-[Co(bpy)2X2]+ (X = Cl or NO2-) and cis-[Co(phen)2Cl]+ ions in presence of (+)-cinchonine hydrochloride and (+)-tartaric acid. Two new chiral environment compounds i.e. (+)-ascorbic acid and (-)-lysine also induce this effect in a few complexes. The effect is used to correlate the absolute configurations of these complexes with that of standard compounds like A-K3[Co(ox)3].
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SYNTHESIS OF CERTAIN HETEROARYL-FUSED 1,3,5-TRIAZINE RING SYSTEMS AS POTENTIAL ANTIMICROBIAL AGENTS

MOHAMED M EL-KERDAWY ,M SAID BAYOMI ,ATIF TANTAWY ,

2-lmino-4-carbomethoxy-s-triazino[2,1-b) benzothiazoles, benzoxazoles, and thiazoles (VI), and XIII were synthesized in combination with their 4-carboxylic acid derivatives (VII) & (XIV), via the cyclization their 4-carboxylic acid derivatives (VII) & (XIV), via the cyclization reaction of their corresponding 2-guanidine salts with diethyl oxalate. Reaction of 4-carbomethoxy-s-triazines with hydrazine hydrate gave the corresponding hydrazides (VIII), from which hydrazones (IX) were prepared. Cyclization of  2-guanidine heterocyclic salts with ethyl chloroacetate afforded 2-imino-4-chloromethyl-s-triazines (V & XII) in fair yields. Some of the synthesized compounds were studied through their ir, nmr spectra. 
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EFFECT OF ORGANIC SOLVENTS ON THE ATOMIC ABSORPTION OF TIN IN AIR-HYDROGEN FLAME: ANALYSES OF FLAME GASES (PART-IV)

I L MARR ,J ANWAR ,

By aspirating butanone into air-hydrogen flame numerous species were produced in the flame. To detect various terminal species and monitor their concentrations the gases from different parts of the flame were pumped into gas chromatograph. The major products detected by this method were light hydrocarbons, oxides of carbon, ketones, alcohols and flame gases like nitrogen, oxygen and hydrogen. The variation in concentration of these species with hyd/air ratio of the flame has been checked. An attempt, based on the evidences obtained in these studies, is made to explain the unsual depression in tin absorption caused by organic solvents in air-hydrogen flame. 
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TRANSITION METAL COMPLEXES OF 2,8-DIMETHYL-6H, 12 H-5, 11-METHANODIBENZO [b, f] [1,5] DIAZOCINE

SAEED UR RAHMAN ,

The titled compound (EPHZ) can be compared with 5:6:11:12:-tetrahydro-2:8-dimethylphenhomazine (PHZ) and 5:6:11-trihydro-2:5:12-trimethylphenhomazine (MPHZ) in its structural characteristics on coordination to several transition metals. In EPHZ both the amines are bridged through the methylene group and thus providing more room for fifth and sixth coordination. EPHZ forms bis-complexes with cobalt (II), cooper (II), mercury (II) and cadmium (II). The molecular structure of these complexes is assigned on the basis of analytical, spectroscopic, magnetic, and conductance data. The thermogravimetric studies are reported and discussed. The ligand is characterized by its mass spectra. 
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A NEW METHOD FOR STUDY OF MIXED COMPLEXES IN SOLUTION (M-NITRILOTRIACETATE-THREONINATE SYSTEM)

S SINGH ,P MUMAR ,K L YADAVA ,R CHANDER ,S R TRIPATHI ,

A new method, involving the use of paper electrophoresis is described for the study of equilibria in mixed ligand complex systems in solution. This method is based on the migration of a spot of a metal ion, with the complexants added in the background electrolyte (0.1M perchloric acid). The concentration of one of the complexants (NTA) is kept constant,while that of second ligand (threonine) is varied. A graph of log threonine against mobility is used to obtain information on the formation of mixed ligand complex and to calculate the stability constants.
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SOME REACTIONS WITH 2:3 INDOLONE DERIVATIVES

S S IBRAHIM ,E A MOHAMED ,R M ABDEL RAHMAN ,A M ABDEL HALIM ,

1,2,4-Triazol (4,3-a)-indol-3-one, N1-(5-thioxo-1,2-dihydro-1,2,4-triazol-3-yl) indol-2,3-dione, indole-(3,2-b) quinoxaline, 4,5-tetrahydro-1,3-diazin (2,1-a) indol-3-hydrazone, 5,6-substituted 1,2,4-triazine-3-one, 1-(3-imino indol-2-one) pyrimidin-2,4 dione, 3-[2-(5-benzylidene-4-thiazolidinone) diazol indol-2-ones and 2-thioxo-1,3-diazin-5-one derivatives have been synthesized through the interaction between indole-2,3-dione and various bifunctonal compounds. 
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FURTHER STUDIES ON ACETYLENIC (beta)-DIKETONES, AND THEIR CONVERSION INTO 3-CHLORO-4-PYRONES

I EL.S EL-KHOLY ,M M MISHRIKEY ,M G MAREI ,

The mass spectra of 1,5-diarylpent-1-yne-3,5-diones (Ia-e) is studied for the first time. The 3-chloro-4H-pyran-4-ones were obtained from the corresponding acetylenic (beta)-diketones by the action of N-chlorosuccinimide (NCS). The intermediate 4-chloro acetylenic (beta)diketones (7a, d) could be cyclized to the pyrones (9a, d), which gave 3-chloro-1-hydroxy-4-pyridones (13a, d) or isoxazole derivatives (14a, d) with hydroxylamine.
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SYNTHESIS OF SUBSTITUTED PYRIDINE, NAPHTHYRIDINE AND PYRIDO-PYRIMIDINE DERIVATIVES

AFAF A.A ELBANANY ,

Compound (1) reacted with malononitrile, phenyl isothiocyanate, urea and thiourea to give the pyridine derivatives (3), (4) and (6) respectively. Compound (2) reacts with the same reagents to give the naphthyridine derivative (8) and the pyrido-pyrimidine derivatives (9) and (10) respectively. 
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