VOLUME 8, NO3, SEPT 1986
123
 
Synthesis and Reactions of Some 2-Aryl-4-Arylidene-5 ( 4)-Oxazolones

M A I SALEM ,A A AFIFI ,S S EL KADY ,M A HASHASH ,

Synthesis and Reactions of Some 2-Aryl-4-Arylidene-5 ( 4)-Oxazolones
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Anodic Oxidation of a-naphthol Derivative A Facile Route to Ring Closure Products

E A EL HALEEM ,N ISMAIL ,M EL MOBAYED ,G A EL ENEIN ,

The anodic oxidation of a-naphthol derivatives lead to the formation of naphthoxenium-ion which in the absence of another nucleophile adds to the ca rboxyl group attached to the side cha in in the 4-pos it i on. I n fact the ring closure product depends on the side chain length and the group attached to the side chain.
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Identification of Arachidonic Acid in Lipids of Petersia africana

O N OGBEIDE ,

The 1 ipid extract prepared from the bark of the West African Petersia africana was found to contain arachidonic compound (C.20:4) in substantial amount. The pure compound after isolation by preparative gas­liquid chromatography (glc) was identified by both physical and chemical methods. In addition other fatty acids linoleic (C 18:2), oleic (C 18:1), palmitoleic (C 16:1) myristoleic (C 14:1) lauroleic (C 12:1) were also found. The lipid fraction proved to contain triacylglycerol, cholesterol ester, hydrocarbons and glycosides. This is the first report of the detec­tion of arachidonic compound in P.africana.
Pages(311)
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Effect of Temperature and Thermodynamic Quality of Solvent on Viscosity of Polystyrene

A RAUF ,M K BALOCH ,S H MUGHAL ,

The intrinsic viscosity [n] of polystyrene is investigated with respect to temperature (15°-45°C) and thermodynamic quality of the solvent. These measurements are made using the pure as well as mixed solvents (solvent/non-solvent). From the observations, it is proved that one gets a maximum in the intrinsic viscosity, when it is plotted against temperature, secondly the [n] decreases with the decrease in the thermodynamic quality of the solvnet.
Pages(315)
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Nitriles in Heterocyclic Synthesis: A Route for Synthesis of Functionally Substituted Thiazinones

N S IBRAHIM ,N M ABED ,

The reaction of thiosalicylic acid with a variety of activated nitriles is described. Several new benzo [e]-l,3-thiazinones are reported.
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Chlorosulphonation of Thiophene and Furan-2-Carboxanilides

O O SHODE ,F J SWINBOURNE ,R J CREMLYN ,

Thiophene-2-carboxanilide, the £-chloro,bromo, nitro derivatives and N-(2'-pyridyl) thiophene-2-carboxamide reacted with chlorosulphonic acid to give the sulphonyl chlorides (I, VIII, XIV, XVI, XVIII). The yields were comparatively low when electron-withdrawing groups were present, e.g. nitro and 2-pyridyl. With the £-carboxy derivative only thiophene-2-carboxylic acid was isolated and the £-methyl derivative gave an unidentified product. Furan-2-carboxanilide with chlorosulphonic acid afforded the sulphonyl chlo­ride (XXII). With the unsubstituted heterocyclic carboxanilides, sulphona­t i on occurred in the phenyl ri ng to gi ve (I, XX I I) but with subst ituted anilides reaction occurred preferentially in the 4-position of the hetero­cyclic nucleus. The spectral data of the compounds are briefly discussed.
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Some new derivatives of Imipramine[lO,ll-Dihydro-N, N-dimethyl( -5H-dibenz (b,f) azepine-5-Propanamine)] and Chloroquine [7-chloro-4-(4-diethylamino-l-methyl butyl amino quinoline)]

B S SIDDIQUI ,S S AHMAD ,S SIDDIQUI ,S I HAIDER ,

von Braun (BrCN) reaction and its extension carried out on imipramine resulted in the formation of N-cyano, N-amido and N-dimethyl amino-(diamine) derivatives. On the other hand, chloroquine on reaction with BrCN yielded three cyano derivatives. All these derivatives have been characterized through spectral studies.
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Some New 2-Methyl-4-[Piperazinylcarbonylethyl/ ethenyl/o-phenylenyl carbonyloxy]-6,7-Substituted Quinolines as Possible A nticonvulsants

E SINGH ,M I HUSSAIN ,M AMIR ,

Twenty four new 2-methyl-4-[piperazinylcarbonylethyl/ethenyl/ o-phenylenylcarbonyloxy]-6,7-substituted quinolines were synthesized by the condensation of 2-methyl-4-hydroxy-6,7-substituted quinoline with pipera­zinylcarbonyl acid' chloride in pyridine. Some of the compounds at a concentration of lxlO-3 mol/litre inhibited rat brain monoamine oxidase (MAO) in vitro and provided protection against pentylenetetrazole-induced convulsions in mice.
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Studies on the Chemical Constituents of Azadirachta indica A .Juss (Meliaceae) Part-VI [1]

S FAIZI ,S SIDDIQUI ,B S SIDDIQUI ,T MAHMOOD ,

A new triterpenoid, nimolinone (I) has been isolated from the fresh, uncrushed, ri pe fruits (ni mo 1 i) of Azadi rachta i ndi ca and its structure elucidated through spectral and chemical studies.
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Studies on some Dioxouranium (VI) Complexes of N-Dimethylthioformamides Part II

A O BAGHLAF ,A H AL SHAIKH ,M ISHAQ ,

Dioxouranium (VI) complexes of N-dimethyl-thioformamide were prepared on treatment of uranyl ch 1 ori de and uranyl ni trate with the li gand in 1: 2 mole ratio in absolute alcohol. The complexes were characterised by IR spect­roscopy and by their elemental analysis.
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