VOLUME 1, NO1, SEPT 1979
12
 
Isolation and Structure of Ajmalinol - a New Alkaloid From Rauwolfia comitoria Afzuelia

A MALIK ,S SIDDIQUI ,

A new phenolic dihydroindole alkaloid has been isolated from Rauwolfia J'omitoria Afzuelia and provisionally named as ajmalinol. It could be identified as ll-hydroxy ajmaline through chemical and spectral evidence. 
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AminoAcid Sequences of the (alpha) and (beta) chains of Adult Hemoglobin of the Patas, Monkey, Erythroc;ebus Patas

K FUKHUSHIMA ,M KUWAHARA ,T MAITA ,M GOODMAN ,G MATSUNDA ,N AIZAWA ,

Globin prepared from hemoglobin of the patas monkey (Erythrocebus patas) was separated into 0< and (3 polypeptide chains by chromatography on a eM 52 column .. After 8-aminoe­thylatiol), both chains were digested with trypsin and the amino acid sequences of thc tryptic peptides obtained were analyzed. Further, the order of these tryptic peptides in each ,chain was deduced from their homology with the primary structures of a and (3 chains of human adult hemoglobin. Comparing the primary structures of the a and (3 chains of adult hemoglobin of the patas monkey thus obtained with those of human hemoglobin, 5 amino acid substitutions in the a chains and 7 in the (3 chains were recognized.
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Synthesis of (alpha) (Diphenylphosphinoyl)Ketones by Acylation of Alkyl Phosphine Oxides

S WARREN ,R S TORR ,

Direct acylation of primary alkyl diphenylphoThine oxides with butyl-lithium and carboxylate esters is a general synthesis of Ph2PO. CHR 1. CO. R . 
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Approaches to the Mitomycins: Oxidation of 2,5.Dimethoxy.4.methylacetophenone with Thallium Trinitrate

R W FRANK ,K J FALCI ,

Multiple reactivity of the title acetophenone with TIN is described. Hithertofore undescribed solvent effects are reported.
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Chemical Investigation of Anticharis Linearis Hochst, Parton (Structure of Linearin and Linearoside )

M A KAZI ,I M KHATRI ,

Linearin and linearoside have been assigned the structures as shown by fig-l and flg-2 respectively, mainly based on spectral interpretation and comparison with other known iridoids. Linearoside is' a j3-D-glucoside of linearin as confirmed by enzymatic hydrolysis.
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Characterisation of (beta)-Hydroxytyrosine Units in Ristocetin A

D H WILLIAMS ,A F NORRIS ,V RAJANANDA ,

Ristocetin A is shown to contain a fragment formally derived by phenol oxidative coupling of two P-hydroxytyrosine units to a p-hydroxyphenylglycine
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Molecular Basis of Sweetness

R KHAN ,

Some of the theories in the perception of sweetness are reviewed. The sweetness of some chlorodeoxy sucrose andgalactosucrose derivatives is examined in relation to conformation and conIJgU1'ation. The presence of more than one 'g1ucophore' system in these derivatives is proposed.
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The Crystal Structures of Ammonium Phosphinate (Hypophosphite) and Guanidinium Ph08phinate, and the Cell Parameters of Hydrazinium(2+) Phosphinate

T J R WEAKLEY ,

In (NH4)H2P02 [Cmma, a = 7.515(6), b = 11.50(1), c = 3.988(4) A, Z = 4 J the anion has accur,ately C2v symmetry, with P-O 1.500 A and a o-P-Q angle of U5.1°. In (CH6N3)H2P02 [Pnam, a = 9.561(8), b = 7.401(5), c = 8.541(5) A, Z = 4 J the anion occupies a site of symmetry m, with similar dimensiori. In botli compounds a hydrogen-bond network extends throughout the crystal (N .. O 2.84 to 3.02 A) and involves all H atoms of the cation. Structures were solved from, respectively, diffractometer data (R 0.074 for 210 reflections) and photographic data (R 0.074 for 488 reflections). The cell parameters of (N2H6)(H2P02)2 are: P21/c, a = 7.74(1), b = 6.44(1), c = 6.77.(1) A, (3 = 98.1(1)°.
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Oxidation of Some Organic Substances with Cobalt (III) Acetate as Redox Titrant

J ZYKA ,J DOLEZAL ,M HANIF ,

Cobalt (1I1) acetate solution, prepared in glacial acetic acid by the anodic oxidation and sl)Qwing as high redox potential as about 1.4 in various acidic media has been successfully utilised as a Volumetric redox titrant for the determination of hydroquinone, p-tetrachlorohydroquinone, ascorbic acid, p-aminophenol and p-phenylenediamine.
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The Extents of Reduction of the Cystine Residues in the Low-and High-sulphur Proteins of Partially-reduced Wools in relation to the Microfibril-Matrix Structure of the Cortex

A ROBSON ,R R KHAN ,

The disulphide bonds of two samples of Merino 70s wool were reduced to the extent of 38% and 56% respectively and S-carboxymethylated with iodo (2-14C)-acetate.The disulphide bonds remaining intact after these lust-stage reductions were reduced subsequently and S-earboxy­methylated with non-radioactive iodoacetate. The two major low-sulphur proteins of wool (Com­ponents 7 and 8), three high-sulphur proteins (SCMKB2·A, -8 and-C), and a a<-helical polypeptide fraction were isolated from each of the two 14C-Iabelled wools, and the extents to which the half­cystine residues in all of them were reduced in the first stage determined by their contents of 14C, S-earboxymethylcysteine, cystine and cysteic acid. At both levels of lust-stage reduction the low­sulphur proteins were reduced to a much higher degree than either the high-sulphur proteins or the ae-heJical protein fraction. However, although the percentages of half-cystine residues reduced at the 38% level were very different in the two types of protein, the numbers of half-eystine residues reduced per molecule were approximately the same. This lmding, and other evidence, suggests that the disulphide bonds that are more easily reduced in wool are interchair. disulphide bonds linking low­and high-sulphur proteins in the microfibril-matrix structure of the cortex.
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