Journal of The Chemical Society of Pakistan Current Impact Factor is 0.7

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Design, Synthesis and Biological Evaluation of Several Novel 4-aminoquinazoline Derivatives as Potent Anti-Tumor Agents

A series of 4-aminoquinazoline derivatives were designed and synthesized as epidermal growth factor receptor (EGFR) inhibitors in our group. The bioassay results showed all the target compounds possessed potential anti-tumor activities against on A549 and H1975 cell lines. The IC50 values of 8.35 (for A549) and 19.18 μM (for H1975) exhibited remarkable inhibitory activity of compound 7d, which were better compared to the positive control Afatinib (IC50 = 10.41 μM for A549, IC50 = 24.96 μM for H1975). In addition, the molecular docking and ADME prediction of compound 7d was carried out. The more

Liang-Liang Chi, Zhi-Qiang Cai, Bo Wang, Wei-Tao Qin, Ya-Nan Wang, Qiao-Qiao Feng and Wen-Jie Ren

Synthesis and Characterization of Sweet Potato Starch Biocomposite Incorporated with ZnO Nanoparticles

The rapid rise in the production of hazardous waste in the environment, particularly single-use plastics, has prompted the development of sustainable yet cost-effective alternatives. This research aims to create bioplastic films using renewable energy sources. To prevent toxic side products, the composite bioplastics synthesized from sweet potato starch are incorporated with biogenically synthesized ZnO NPs. Biocomposite films were characterized by their morphology, water vapor permeability (WVP), biodegradability, thermal and mechanical properties. It was noted that the ZnO NPs had more

Saira Iqbal, Arjumand Iqbal Durrani and Ashi Rashid

A Sensitive Spectrophotometric Determination of Silver(I) with Blue Tetrazolium Chloride

Silver(I)-assisted reduction of Blue tetrazolium chloride (3,3′-(3,3′-dimethoxy[1,1′-biphenyl]-4,4′-diyl)-bis(2,5-diphenyl-2H-tetrazolium) dichloride, BTC) by semicarbazide hydrochloride (SCH) was investigated in water-chloroform medium. The obtained colored products can be used for the visual detection and sensitive liquid-liquid extraction–spectrophotometric determination of Ag(I). Under the optimum conditions the calibration curve (which can be best approximated by a third-order polynomial; R2=0.9990) has two linear segments. For Ag(I) concentrations up to 0.011 g/ml, the linear more

Vidka Vassileva Divarova, Denitsa Dimitrova Kiradzhiyska and Kiril Blazhev Gavazov

Synthesis, Spectral Characterization and Biological Evaluation of Platinum (II) Complexes of 1,3,4-oxadiazole-2-thione from Fatty Acids

The fatty acid can be separated by separation techniques according to degree of unsaturated and chain length. In this paper fatty acid methyl esters are separated by Argentation Chromatography then converted to 1, 3, 4-oxadiazole. Platinum complexes of 1, 3, 4-oxadiazole are synthesized and Oxadiazole-2-thione ligands containing C=N and C=S groups as coordination sites may behave as a monobasic monodentate ligand. Antioxidant activity of complexes are measured by DPPH assay and in vitro cytotoxicity of the synthesized complexes measured against two human cancer cell line by MTT assay. In more

Saber Salim, Mohamad Hikmat and Aziz Madzlan

Papaverine Derivatives, a Potent Inhibitor of Neuroinflammation in Epileptic Seizures, A Pharmacological and In-Silico Approach Against TNF-α as a Targeted Receptor

Epilepsies are a heterogeneous group of disorders expressed in terms of propensity to experience spontaneous recurrent seizures attack. Verapamil, a synthetic amide derivative containing papaverine, is a calcium channel blocker that significantly reduces the frequency of seizures. Based on this, the current work was planned to concentrate on the synthesis of more recent papaverine derivatives that contain amides. Z1 and Z2 were created using synthesis. Following synthesis, docking analysis was performed, and bond energies were computed to determine their binding affinities against the TNF- α more

Zeenia Tariq, G.A. Miana, Madiha Kanwal, Muhammad Fahim and Sumra Malik

Phytochemical Composition and Antibacterial Properties of Surface Extracts of Six Salvia Species

The chemistry and biological activity of cuticular waxes and the secondary metabolites produced in the indumentum of different plant organs has been attracting the interest of botanists. This work was aimed to investigate the chemistry and antibacterial activity of the surface extracts (SE) of different organs of six Salvia species. The cuticles and indumenta of the leaves, calyxes, and stems of Salvia atropatana Bunge., S. lachnocalyx Hedge., S. ceratophylla L., S. palaestina Benth., S. persepolitana Boiss., and S. hydrangea DC. ex Benth. were extracted with dichloromethane. The SEs were more

Somayeh Zare, Maryam Parish, Mehdi Zare and Amir Reza Jassbi

Synthesis and Antimicrobial Activity of a Number of 3-substituted-8-allylbenzoxazines and their Hydrobromic Salts

In this study, novel 1,3-benzoxazines 3a–d were synthesized starting from 2-allylphenol (2), formaldehyde and primary amines under Mannich reaction conditions, as well as their ammonium salts 4a–d, which were prepared by reaction of compounds 3a–d with HBr. As primary amines aniline, propylamine, n-hexylamine and n-octylamine were used. Synthesized heterocyclic compounds and their ammonium salts (3a–d and 4a–d) were characterized by elemental analysis, IR and NMR spectra. The antimicrobial activity of the synthesized compounds 3a–d and 4a–d at concentration 15 and 30 mgL-1 against more

Gunay Muzakir Mehdiyeva, Musa Rza Bairamov, Eldar Kochari Gasimov, Fuad Huseynali Rzayev

The Chemical Composition and Antidiabetic, Neuroprotective and Cytotoxic Activities of Soft Hulls (Mesocarp) of Pistachio (Pistacia vera) Fruits

Pistachio (Pistacia vera L.) is an important cultivated plant in the Southeastern Anatolia region and its fruits are widely used in the food industry. The previous studies mostly focused on the food minerals and components. However, there is no study on chemical components and biological activity of the soft hulls of the pistachio fruits. In this study, it was focused on the acetone and water extracts of the soft hulls of pistachio fruits. Hence, the acetone extract was subjected to sephadex LH-20 column chromatography and fractioned into five fractions (Frs. A-E) according to molecular more

Mehmet Akyuz, Lawali Yabo-Dambagi, Basak Simitcioglu, Isik Didem Karagoz, Tuba Aydin, Gonca Gokdemir, Ahmet Cakir and Cavit Kazaz

Phytochemical and In Vitro Biological Evaluation of Roots of Malvastrum coromandelianum (L.) Garcke

Malvastrum coromandelianum (L.) Garcke is a medicinal plant, employed traditionally for the treatment of different human illnesses. This study has been planned to study the chemical and biological aspects of the roots of the plant, using chemical and instrumental analytical techniques. Standard reported protocols were used for phytochemical screening of the crude extract, indicating the presence of terpenoids, steroids, flavonoids, and alkaloids classes of compounds. The extract was analyzed through Gas Chromatography-Mass Spectrometry (GC-MS) to confirm the presence of specific more

Sheema, Salman Zafar, Nazif Ullah, Ishaq khan, and Ghias ud din

Binding Pattern Analysis of Different Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

To the best of our knowledge, the current study could be considered the first comprehensive one based on the application of molecular docking on the non-nucleoside thumb and palm inhibitors to nonstructural NS5B protein for the detailed evaluation of their binding patterns in the corresponding binding regions in the protein. Non-nucleoside thumb and palm inhibitors were docked into the thumb and palm sites of the nonstructural NS5B protein which is the RNA-dependent RNA polymerase, respectively. Two docking programs, AutoDock 4.2 and AutoDock Vina were employed for the docking of thumb more

Marium Bibi

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