COMPLEXES OF Fe(III), Co(II) AND Zn(II) WITH THIOCARBAMYLDITHIOCARBAMATE AND THEIR ANTIBACTERIAL ACTIVITY

A number of coordination compounds of a new ligand thiocarbamyldi-thiocarbamate (TCDTC) with Fe3+, Co2+, Cu2+, and Zn2+ ions have been synthesized. The ligand is unstable and cannot be isolated from its reaction mixture, however it readily forms air stable complexes with these metals. These compounds have been characterized by elemental analysis, conductance measurements, absorption and infra-red spectra studies. The compounds (Fe(tcdtc)2Cl.H2O], [Co(tcdtc)2 (H2O)2]H2O and [Cu(tcdtc)2 (H2O)2] have an octahedral structure with tcdtc coordinating through its S1, S3 atoms forming six membered chelates. The complex [Zn(tcdtc)2] H2O has tetrahedral arrangement of ligands around the metal atom. The complexes [Co(tcdtc)2. (H2O)2]H2O and [Cu(tcdtc)2(H2O)2] show antibacterial activity against B. subtilis, V. Cholrea and E. coli wile [Fe(tcdtc)2Cl.H2O] shows very little activity against E. coli and B. subtilis.

NASIR AHMAD ,S. TANSNIM HASSAN ,CHRISTY MUNIR ,