Lactarn acetals undergo facile e1ectrophilicsubstitution at II positioH with araldehydes to fonn benzhydrols. Both threo and erythro products are formed, their proportion depending upon the aldehyde; the products unfacile dehydration to form (E)-ll-benzylidene derivatives. Ibc threo oamino benzhydrols obtained as the exclusive products by reaction of lactarn acetals with amin aldehyde undergo instantaneous cyclisation to give a novel one pot synthesis of l-substituted azacycloalkano (2, 3-b )quinolines.
P C JAIN ,J SINGH ,V VIRMANI ,N ANAND ,
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