A charge transfer complex is formed when antihistaminic drug react with m-dinitrobenzene in basic medium. This complex is used for the determination of antihistamine (cyclizine hydrochloride) in pure and pharmaceutical formulations. The purple color complexes formed are quantified spectrophotomertrically at 540nm. Different statistic parameters like standard deviation, relative standard deviation, slope; intercept and coefficient of determination are calculated. The proposed method can be used successfully for routine analysis of cyclizine hydrochloride in pure and in dosage forms.

Amjad Naseem and Amina Mumtaz