Different analogs of 1-ethyl-1, 4-dihydro-7-methyH-4-oxo-1, 8-naphthyridine-3-carbohydrazide (carbonyl hydrazone derivatives of Nalidixic acid, H 1-10) and their copper complexes have been synthesized from reaction of Nalidixic acid hydrazide with substituted benzaldehyde. These are characterized on the basis of IR spectra, 1H-NMR spectra, Mass spectra, elemental and AAS studies for metals. Copper complexes were prepared from CuCl2.2H2O and these ligands, the metal ligand ratio was found to be 1:1 and found to be bidentate. The antibacterial, antifungal and antioxidant activities of these hydrazone ligands and their copper complexes have also been evaluated. Copper complexes possess antibacterial and antifungal activities better than the parent hydrazone ligands while they have better antioxidant activity with DPPH radical than copper complexes. Nalidixic acid have maximum of all biological activities, but H-6 showed slightly better antioxidant activity than Nalidixic acid and other activities were close to it.
Farah Deeba, Misbahul Ain Khan, Naeem Abbas, Rauf Ahmad Khan and Muhammad Muneeb Ahsan
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