Alkylation of adenosine-5'-monophosphate (5'-AMP) with alkyl halides under strongly alkaline conditions has been investigated. Reaction with methyl-,ethyl-, normal and iso-propyl iodides using a mixture of 1N NaOH and dioxane gave predominantly sugar substituted derivatives. The structure of major products, with special reference to orientation of alkyl groups at the ribose moiety, has been established through U.V. and NMR spectroscopy, and through paper chromatography.
M KHURSHID ALAM KHAN ,GULZAR AHMAD ,
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