The present study reports on the antioxidant potential of five cyclopeptide alkaloids isolated from Zizyphus oxyphylla including Oxyphylline-D 1, Nummularin-C 2, Nummularin-R 3, Oxyphylline-B 4, Oxyphylline C 5 using DPPH free radical assay, nitric oxide radical assay and reducing power assay. The isolated alkaloids demonstrated marked antioxidant potential in a concentration dependent manner. Among the tested molecules, the compounds, 2 was most potent with IC50 values of 27.23, 32.03 and 22.45 µg/ml in DPPH free radical assay, nitric oxide radical assay and reducing power assay respectively.
Waqar Ahmad Kaleem, Naveed Muhammad, Haroon Khan, Abdur Rauf, Muhammad Zia-ul-Haq, Mughal Qayum, Amir Zada Khan, Muhammad Nisar and Obaidullah
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