Samples of effluents from different industries at Amangarh, Nowshera and receiving Kabul River water were analysed for various parameters like; pH, D.O. suspended solids, electrical conductivity, alkalinity, hardness, COD, NO2-N, NO3-N, chlorides, sulphates, Na+, K+ etc. The results indicate localized pollution within half kilometer after the confluence point where the quality of the river water is being deteriorated The data suggest that the river water in comparison to US rivers and Indus River at Kalabagh and at Tarbella Dam is more saline. Industrial effluents contribute towards increase in the salinity of river water. Presence of appreciable amount of oxygen demanding waste in effluents and in the downstream of the river create a suffocating environment to fish crop.