In this study, we report the one-pot synthesis of 2-amino-3,5-dicarbonitrile-6-thio- pyridines with benzaldehyde, malononitrile, and thiophenol by using phosphotungstic acid as an efficient catalyst in aqueous media. This method has the advantages of easy separation, high storage stability, and environmental friendliness.

Miao Shen Su, Xiao Jing Ji, Bing Bing Zhao, Meng Tian and Jing Jun Ma