In this study, the preparation and characterization of hesperidin-PEG 6000 solid dispersion were investigated. The ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD) and Differential scanning calorimetry (DSC) were used to analyze the physicochemical properties of the complex. By forming the complex with polyethylene glycol 6000 (PEG 6000), the solubility of hesperidin in water could be significantly improved. UV spectra and IR spectrum showed that there was no obvious difference between hesperidin and the complex. The XRD pattern of the complex suggested that hesperidin in the matrix was either molecularly dispersed or in amorphous form. DSC analysis implied that hesperidin had been completely dispersed in PEG6000 and there were some interaction between hesperidin and PEG 6000. The results showed that hesperidin in the complex had been completely dispersed in the PEG 6000, not forming a new compound.

Haiyan Gao, Yuzhen Chen, Hanjun Ma, Jie Zeng and Guanglei Li