PREPARATION OF SOME 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPINES AND STUDY OF THEIR PHYSICAL AND SPECTRAL PROPERTIES

Preparation of 4-methyl-(1), 3-methyl-(2), 2,2- dimethyl-(3) and unsubstituted -(4), 1,3,4,5-tetrahydro-2H-1:5- benzodiazepines has been accomplished by LiAIH4 reduction of corresponding 1,3,4,5-tetrahydro-2H-1:5-benzadiazepin-2-ones (5- 8). Physical properties, mass and H-1 n.m.r. spectral properties of 1 - 4 have been described, whereas those of 5 - 8 are being published elsewhere. Carbon-13 n.m.r. spectral properties of 1 - 8 are included in this paper. All these compounds will be subjected to dynamic H-1 n.m.r. spectral studies in order to obtain information regarding the effect of methyl- and carbonyl - substitution on the solution conformation of medicinally important 1,3,4,5-tetrahydro-2H 1:5-benzodiazepine ring.

Z MAQBOOL ,F MALIK ,M HASSAN ,M C G ALVAREZ ,