Synthesis, Characterization, Crystal Structures, Analgesic and Antioxidant Activities of Thiourea Derivatives

1-(2-chlorobenzoyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)thiourea (Cl2AAP) and 1-(2-chlorobenzoyl)-3-(pyridine-2-yl)thiourea (Cl2AP) were synthesized and characterized by spectroscopic methods (FT-IR, 1H NMR) and single crystal X-ray diffraction. Both compounds crystallized in monoclinic system and solved in P21/n, Z = 4 and P21/c, Z = 12 space groups respectively. Pharmacological screenings of the synthesized compounds have shown comparable analgesic activity to that of the standard diclofenac sodium at 30 mg/kg body weight dose. The DPPH and ABTS free radical scavenging activity of Cl2AAP are more significant than Cl2AP as compared to standard (IC50= 10, 60; 45, 75; and <10 µg/ml for standard Ascorbic acid respectively).

Mohammad Shoaib, Shafiullah, Muhammad Ayaz, Muhammad Nawaz Tahir and Syed Wadood Ali Shah