Catalytic effects of several solid adsorbents on the adsorbed metal nitrates towards oxidation (dehydrogenation) of isopropanol to acetone in the absence of any co-solvent have been studied. The efficacies of some commercial adsorbents as well as some indigenously available natural clays as catalytic supports have been evaluated. Transition metal nitrates have been found to be better supported oxidizing reagents than the alkali and alkaline-earth metal nitrates. A simple spectrophotometric method has been developed to monitor the amount of acetone formed during isopropanol oxidation.