E-Ch 1 orobenza 1 dehyde and benza 1 dehyde a re condensed wi th di ethy 1 cyclohex-l-enyl succinate in the presence of potassium !.-butoxide to give trans(C6H4Cl/COOEt)-half-esters. Saponification gave the corresponding dibasic acids. The half-esters are cyclised to acetoxy-naphthoates which a fforded the correspondi ng hydroxy- and methoxy-naphthoi c aci ds. Benzofluorenones (4a,b) are obtained from the methoxynaphthoic acids on treatment with phosphorous pentoxide. The diacid (2b) is converted to .E.-chlorobenzylidene-l,2,3,4-tetrahydroindanone which is cyclised, saponified and methylated to give the same methoxybenzofluorenone (4a). The biological evaluation of these compounds is discussed and showed a good activity against bacterial strains.
H A A REGAILA ,O M H EL ROUDI ,
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