Phenobarbitone-Na reacts with amino acid in alkaline media after heating for 3min at 100oC to give an orange yellow color having maximum absorbance at 330nm. The reaction is selective for phenobarbitone-Na with 0.01mg as visual limit of identification and provides a basis for a new spectrometric determination. The color reaction obeys Beer’s Law of 0.01 mg to3 mg/ml of Phenobarbital-Na and the relative standard deviation is 0.85%. Other drugs like atropine, phenytoin-Na benzodiazepine/chlorpromazine, etc were also studied for the inferences in the developed procedure.
T AMAN ,A HASSAN ,S FIRDOUS ,I U KHAN ,
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