Investigation of the Efficiency of Aminoalcohol Based Catalysts in the Addition of Diethylzinc to Aldehydes

In this study, firstly, two amino alcohols, namely, (2S)-2-[Benzyl(2-hydroxyethyl)amino]-3-methyl-butan-1-ol (1) and (2R)-2-[Benzyl(2-hydroxyethyl)amino]butan-1-ol (2) were prepared in 89 and 94% yields, respectively, and their structures were elucidated by spectroscopic methods. Then, the catalytic activities of these amino alcohols in the reaction of diethylzinc addition to benzaldehyde and its derivatives were investigated. The catalytic activity of these amino alcohols in the diethylzinc addition reaction to benzaldehyde under the optimum conditions was determined as 96% conversion and 40% ee.

Nevin Arslan