For the treatment of iron overload, a drug desferrioxamine mesylate has been used. It is linear trihydroxamic acid, a natural siderophore produced by streptomyces which removes the extra iron from body. Salicylhydroxamate is a simple model of hydroxamate type siderophore. In present research salicylhydroxamate was used for the complexation with tripositive metal ions which are available in biological environments such as AI(III), Cr(IlI) and Fe(lII). The aim of our work was to study the competition reactions between Fe(II1) and other tripositive ions, to calculate the thermodynamic data of chelation of these metal ions complexes with hydroxamate by computer program and comparison with iron hydroxamte complexes.
F S REHMANI ,
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