Two different synthetic approaches viz. reductive cyclization of N-heterocyclyl-2-nitrobenzanilides (3) and the base catalysed cyclization of 2-azido-N-heterocyclylbenzanilides (7) were adopted towards some new 2-heterocyclylindazol-3-ones (4). However, both methods proved to be less successful tend bared upon the results of these investigations, a safe strategy involving the heteroarylation at N-2 of the 1-carboethoxyindazolone giving (8) followed by deprotection at N-1 to furnish (4) was suggested for preparation of 2-hetetocyclyindazolones.
AAMER SAEED ,NASIM H RAMA ,
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