Synthesis of Benzophenone Hydrazone Analogs and their DPPH Radical Scavenging and Urease Inhibitory Activities

Benzophenone hydrazone analogs 1-25 were synthesized and evaluated for antioxidant (DPPH radical scavenging), and urease inhibitory activities. Out of twenty-five analogs, compounds 8, 23, and 1 showed potent free radical scavenging activities with IC50 values 19.45 ± 1.25, 21.72 ± 1.49, and 26.0 ± 0.52 μM, respectively, while compound 8 (IC50 = 36.36 ± 0.94 µM), and 15 (IC50 = 55.5 ± 0.69 µM), showed good to moderate urease inhibitory potential.

Khalid Mohammed Khan, Fazal Rahim, Ajmal Khan, Sajjad Ali, Muhammad Taha, Syed Muhammad Saad, Momin Khan, Najeebullah, A. Shaikh, Shahnaz Perveen and Muhammad. Iqbal Choudhary