Biocompatible Membranes and Coatings for Glucose Sensor

This paper describes the preparation as well as evaluation of biocompatible membranes and coatings, for an amperometric glucose sensor in order to extend the linear range of the sensor characteristics. For this purpose, both Nafion and polyurethanes are highly suitable, as they increase the upper limit of linearity up to a factor of five. Nafion membranes underwent optimization of their diffusion behavior by temperature-controlled pressing. Sensors with coatings showed much smaller response times (one minute) than with membranes. In both cases, we achieved detection limits of 0.3 mmol/l glucose with a linear sensor characteristic of up to 10 mmol/l compared to 1.4 mmol/l for the unmodified electrodes. Furthermore, polymer coatings and membranes prevent clogging of the sensors by the bioanalytes.

USMAN LATIF, FRANZ LUDWIG. DICKERT, RALPH-GUNTHER BLACH AND HANS-DIETER FEUCHT