Synthesis of Some Cytidine Derivatives and Their Antibacterial Effects

Reaction  of cytidine-component  of RNA-with   alkylating  agent  (such  as methyl iodide)   and   subsequent halogenation    led  to  the  synthesis  of novel   compounds   which  are expected  to  be  molecular medicines,   These have  been  identified  and  characterised by   paper chromatography,    UV   and  'H-NMR   spectroscopy.  Amongst them the 2'-O-methyl-5-bromo-cytidine   (2'-O-m-5-Br-cytd)   has   shown   significant   inhibitory   effects  of   some   common pathogenic bacteria. The overall results are reported in this paper.

M QUDRATEKHUDA ,R ZUBERI ,K F AZHAR ,