Malvastrum coromandelianum (L.) Garcke is a medicinal plant, employed traditionally for the treatment of different human illnesses. This study has been planned to study the chemical and biological aspects of the roots of the plant, using chemical and instrumental analytical techniques. Standard reported protocols were used for phytochemical screening of the crude extract, indicating the presence of terpenoids, steroids, flavonoids, and alkaloids classes of compounds. The extract was analyzed through Gas Chromatography-Mass Spectrometry (GC-MS) to confirm the presence of specific phytochemicals. The extract exhibited biological activities at good to moderate levels and was found to be non-toxic. Moderate inhibitory potential was observed against Aspergillus niger, Fusarium solani, Candida albicans, Klebsiella pneumoniae, Bacillus subtilis, Proteus mirabilis, Escherichia coli, and Staphylococcus aureus. At a concentration of 1000 μg/ml the crude extract showed 67 % inhibition of the Leishmania tropica promastigotes. The extract also displayed moderate radical scavenging activity. Interestingly, it showed lower red blood cell hemolysis (28%) at the highest concentration. The biological potential of the crude extract may be credited to these metabolites, as most of them have been previously reported to have the same activities.

Sheema, Salman Zafar, Nazif Ullah, Ishaq khan, and Ghias ud din