The in vitro antimicrobial activities of eight newly synthesized disperse dyes has been studied using agar-well diffusion method. Three Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis) and eight Gram negative bacteria (Klebsiella pneumoniae, Proteus sp, Pseudomonas aeruginosa, Salmonella typhi and S. para typhi B, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, and Vibrio cholrae) were employed. The dyes were previously synthesized based on substituted pyridines and its derivatives and the structural characterization revealed that they contain a pyridine nucleus in their structure. The antimicrobial activity was performed using a dye solution (100 mg/ml). The dyes demonstrated varying degrees of activities against different bacterial cultures tested which highlighted the fact that their chemistry has significant influence on the antimicrobial activity.
Zeeshan Akhtar, Syed Imran Ali, MuhammadYasirKhan, Zafar Iqbal Shams, Shagufta Afaq, Kamran Ahmed and Rasheeda Parveen
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