The binding of Pt(II) and Pd(II) ion 4-amino-2,5-dimethyl-1-pyrimidine (ADMPY) has been compared with the binding of the same metal ions to 2,5-dimethyl-4-hydroxy pyrimidine (HDMPY), analogue of ADMPY in which the amino group has been replaced by a hydroxyl group. A brief comparison is made with the corresponding Pt(II) and Pd(II) complexes of thiamine and oxythiamine. In this paper we report the synthesis, elemental analyses, infrared spectra data, proton and carbon-13 nuclear magnetic resonance studies of these new complexes. A complete assignment of 1H 13C NMR spectra resonances is presented for both the ligand and the complexes. The results show that the metallation site is N-1' position of the ligand in agreement with earlier works [1-3], however, the chemical shifts observed for this ligand upon complexation are larger than the corresponding chemical shifts observed for the 4-amino-2,5-dimethyl-pyrimidine analogue contrary to the thiamine/oxythiamine system.