Synthesis and spectroscopic studies of the complexes of tumor cell differentiating agent hexamethylene bisacetamide with nickel halides

Complexes of the tumor cell differentiating agent hexamethylene bisacetamide (HMBA) with nickel(II) halides e.g. Ni-2(HMBA)(3)Cl-4 . 2H(2)O, Ni-2(HMBA)(3)Br-4 . H2O, Ni(HMBA)Cl-2 . H2O and Ni-3(HMBA)Cl-6 . 3H(2)O have been synthesized and characterized by elemental analysis. On the basis of their reflectance spectra and magnetic susceptibility data, the complexes with 2:3 stoichiometry are assigned as mixed octahedral-tetrahedral structures and can correctly be formulated as [Ni(HMBA)(3)][NiX4]. nH(2)O (X = Cl; n = 2 and X = Br, n = 1). On the other hand, the complex Ni(HMBA)Cl-2 . H2O has essentially a tetrahedral structure and the complex Ni-3(HMBA)Cl-6 . 3H(2)O a chloride-bridged polymeric octahedral structure.

MARGARET GOODGAME ,IZHAR HUSSAIN ,