Pyrazolone is considered to be an active nucleus present in a large number of drugs. Based on their biological profile, we have tested previously synthesized series of pyrazolone derivatives (Ia-Id), (IIa-IId), (IIIa-IIId), and screened those for in-vitro antioxidant potential using DPPH assay method. These compounds showed moderate to good antioxidant activity. Furthermore, potential analogs were evaluated for in-vitro cytotoxicity via MTT reduction assay in MCF-7 cell line. The compounds exhibited non-toxic effect and did not show 50% inhibition on particular concentration. Based on these observations, we report here that these analogs can be developed into safe drugs
Madiha Kanwal, Sadia Sarwar, Humaira Nadeem, Benish Saeed and G. A. Miana
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