The reaction of thiosemicarbazide with ethyl acetoacetate leading to the formation of thiosemicarbazone of ethyl acetoacetate (I) and 3-methylpyrazol-5-one-1-thiocarbamide (II) has been studied in the aqueous medium at room temperature. The effect of sonication on this reaction has also been investigated. Parameters for the formation of I and II have been determined. A reaction scheme for the formation of 1 and its subsequent cyclisation to form II has been proposed. The rate of formation of II is greatly enhanced under the influence of sonication.
C M ASHRAF ,S SHAUKAT ALI ,ABID HUSSIAN ,
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