Thirty eight samples of water from Kabul River and its tributaries starting from Warsak Reservoir to the confluence point of Kabul and Indus Rivers covering a stretch of about 90 km and the waste water being discharged by different drains into the river were collected systematically and analysed for total organic strength as Chemical Oxygen Demand (COD) and degradable organics as Biological Oxygen Demand (BOD) using standard methods. River water samples from different locations were also analysed bacteriologically for Fecal coliforms. All the waste water samples and river water at a few locations were found to be high in COD, BOD and Fecal coliform rendering it unfit for irrigation and human consumption The results also suggest that the effluents from Khazana Sugar Mills, Colony Sarhad Textile Mills, Amarjee Paper and Paper Board Mills and from different tanneries are the main sources of organic pollution in the Kabul River. Reduction in fish crop in Kabul River could be referred to the increased organic pollution.