Synthesis of Dihydroxamic Acids from Dinitrones, Structural Characterization and Antimicrobial Activities

The benefits of dinitrones (N,N'-Diphenyl-2,5-thenylenedinitrone, N,N'-Dimethyl-1,4-phenylenedinitrone and N,N'-Dibenzyl-1,4-phenylenedinitrone) in the synthesis were chosen as simple process for synthesis of the purified dihydroxamic acid compounds in a shorter time with a good yield and high purity without need to purification. The most stable conformers of the synthesized compounds and their electronic properties have been determined using DFT/B3LYP calculations. Antimicrobial activity assessment of dihydroxamic acids showed their good efficiency.

Cherifa Mahieddine, Said Zerkout, Sidali Rayane, Houssam Boulebd, Affaf Laassami, Salah Akkal