A number of per-6-substituted-6-deoxy-β-cyclodextrin derivatives have been synthesized for many years, of them, per-6-deoxy-6-iodo-β-cyclodextrin is of great importance in supramolecular chemistry. By reviewing all published papers related to synthesis of per-6-deoxy-6-iodo-β-cyclodextrin and combining with our experimental verification, this work has reported an improved method of synthesis of per-6-deoxy-6-iodo-β-cyclodextrin. The approach mainly uses adding a certain amount of methanol instead of removing DMF before adjusting pH. We think this project is simple, efficient, high repeatable and suitable for large-scale preparation, superior even to all the previously reported methods. The synthesis of bromo, chloro substituted -per-6-β-CD may also refer to this improved method. At the same time, the detailed introduction of operation process and precautions will serve as a reference and guidance to the beginner who will engage in the study on the chemical synthesis reaction of sugar and cyclodextrin.
Suomin Feng, Jiaxing Feng, Guangcan Xu, Jiang Liu, and Yongmin Zhang
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