Circular dichroism studies of complex forming ability of (+)-benzylpenicillin with VO(IV), Cr(III), Co(II) and Cu(II) ions in alcohol water (70 : 30) solution

Formation of complexes of antibiotic (+)-benzylpenicilline ((+)-(BP) with VO(IV), Cr(III), Co(II) ions in EtOH/MeOH:H2O (70:30) solution has been studied through circular dichroism. The optimum conditions of pH, stoichiometry and time for achieving maximum complexation in these systems are reported. Their formation constants are also determined. The CD spectra of these complex ions formed in solution are interpreted.

ABDUL KHALIQUE ,CHISTY MUNIR ,NASIR AHMAD ,