Volumetric and Ultrasonic Studies of an Antidepressant Drug in Aqueous and Alcoholic Medium over Temperature Range 298.15-313.15 K

Escitalopram oxalate is an amphiphilic serotonin specific reuptake inhibitor-antidepressant drug. Ultrasonic velocity (u) and density (d) measurements were carried out for Escitalopram oxalate in aqueous and alcoholic systems as a function of concentration in a range of molality, m = (0.0075-0.04) mol.Kg-1 at 298.15-313.15 K using an Anton Paar density sound analyzer (DSA 5000M). Using these experimental values, the acoustical parameters such as apparent molar adiabatic compressibility (K), apparent molar volume (Vand partial molar volume (V0) was computed for all the systems. The Partial molar expansivity (E0) and second derivative values, (∂2V0/∂T2), have also been estimated. The critical micelle concentrations of this drug were obtained from ultrasound velocity measurement by using recently developed least square fitting algorithm. The results are interpreted in the light of structure-making or structure-breaking effects of escitalopram oxalate in the mixtures.

MUHAMMAD ASGHAR JAMAL, MUHAMMAD KALEEM KHOSA, MAJID MUNEER, FAZAL-UR-REHMAN, KHALID MAHMOOD ZIA AND KHURRAM SHAHZAD