A simple, rapid and accurate milligram method for the determination of chloropromazine hydrochloride (stemetil), promethazine hydrcohloride (Phenergan), and triflupromazine hydrochloride (Stelazine) in the presence of excipients is described. The reaction is made selective to react with N-bromosuccinimide and the heat of reaction is used to determine the end point of the titration. The method has been applied to pure and pharmaceutical formulation. A comparison of the results obtained by using this method and the U.S.P. methods shows no significant difference in the accuracy of the two techniques. The main advantages of the proposed method are less time taken, the potential for automation of the process and ability to carry out assay of single dosage form.
M SIDDIQUI ,U M ABBASI ,M I BHANGER ,
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