A microemulsion-based drug delivery system has been designed for Diclofenac Sodium(DS) comprising Span 60, 1-Propanol, Water, and Lemon Oil. The microemulsion system has beencharacterized by a pseudo-ternary phase diagram using the water titration method. The propertiesand structure of this system have been studied by the use of refractive index, electrical conductivity,viscosity and UV-Visible spectroscopy. The conductivity (σ) and viscosity (kη) measurements haveprovided evidence for percolation behavior with variation in Φ (weight fraction of aqueous phase).This phase transition corresponds to the structural change from water-in-oil to a bicontinuousmicroemulsion system. The percolation threshold (ΦC) obtained from conductivity measurementswas in accordance with that obtained by viscosity measurements. Five microemulsion samples wereselected and the changes in microstructure after incorporation of the drug, Diclofenac Sodium (DS)were examined by centrifugation, conductivity measurements, viscosity measurements andspectroscopic studies. The conductivity measurements showed that DS-loaded samples have higherconductivity values when compared to non-loaded samples. It was also found that DS is interfaciallyactive. In addition, loading of DS had no negative effect on the stability of the system.


NADEEM ABBAS KIZIBASH ,SYED SAKHAWAT SHAH ,DHAIFALLAH ALENIZI ,MOHAMMED FAIZAN NAZAR ,SHUMAILA ASIF ,