Bis(l-deoxy-Q-glucitol) l,l'-disulfide .!.Q and the corresponding l,l'-sulfide Q have been prepared. Nucleophilic displacement reaction of the l-tosylate ~ with potassium thioacetate afforded the l-S-acetate ~ which on deesterification gave the l-thiol-Q-glucitol ~. Oxidation of ~ followed by removal of the protecting groups gave the target compound lQ. The l,l'-sulfide Q has been obtained from ~ by condensation with the l-tosylate 6 followed by cleavage of the acetal groups.
A U RAHMAN ,J R DANIEL ,R L WHISTLER ,
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