Nowadays, biocompatible, and cost-effective material design is one of interesting fields in biological process. In this regard, Magnesium/Aluminum Layered Double Hydroxides (Mg/Al LDHs) synthesized and fabricated with environmental benign anions was investigated like Citrate and Gallate. Furthermore, these modified Mg/Al LDHs were treated with chitosan in order to increase the biocompatibility of the compounds. The Fourier-Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), Energy dispersive X-ray (EDX) and X-ray Diffraction (XRD) analysis confirmed that modification has done successfully. In FTIR the peaks appeared in the range of 3441 cm-1 to 3380 cm-1 were attributed as acidic OH- . Whereas, the metal oxide peaks appeared below 1000 cm-1 showing the successfully intrusion of anions. Moreover, the plate like structure in SEM analysis also confirmed the successful modification of anions. The presence of elemental peaks through EDX including: Ca, P, N as well as Mg, Al and the gap between these layers calculated through XRD endorsed the intercalation of anions in LDHs. The thermal stability profile revealed that the thermal stability of modified Mg/Al LDHs has decreased than pure Mg/Al LDHs due to incorporation of organic segments. These synthetically modified Mg/Al LDHs were evaluated for their Hydroxyapatites [Ca10 (OH) 2 (PO4)6] generation ability in Simulated Body Fluid (SBF) at pH 7.4. The results showed that the modified Mg/Al LDHs have significant Hydroxyapatites (HAPs) generation ability. Moreover, the citrate intercalated LDH showed remarkable bioactivity in term of HAPs generation. Therefore, these modified Mg/Al LDHs have excellent capability to utilize these compounds in various fields like: bone and teeth additives, implant materials as well as bone- tissue engineering.
Sehar Zahid, Waqas Jamil, Mouhammad Taha, Javeria Shaikh and Khalid Mohammad Khan
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