Spectrophotomertric Determination of Mianserin in Pure and Pharmaceutical Preparations

Mianserin reacts with alizarin sulfonic acid (sodium Salt)   to give  a reddish yellow colour having maximum  absorbance at  520 nm.  The  reaction is specific  for Mianserin with  1   µg/10  ml  as  visual  limit  of quantization, and provides  a   basis for  a  new spectrophotometric  determination. The  colour  reaction  obeys  Beer's  Law   from  0.001 µg   to  3.5  µg/10   ml  of  Mianserin.  De   relative standard    deviation is <    0.2%. The method is successfully applied    to  pure  and pharmaceutical  dosage  forms  of Mianserin.  The quantitative assessment of tolerable limits of other drugs not interfering are also studied.

I I KAZI ,T AMAN ,Z A KHAN ,I U KHAN ,