Mianserin reacts with alizarin sulfonic acid (sodium Salt) to give a reddish yellow colour having maximum absorbance at 520 nm. The reaction is specific for Mianserin with 1 µg/10 ml as visual limit of quantization, and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer's Law from 0.001 µg to 3.5 µg/10 ml of Mianserin. De relative standard deviation is < 0.2%. The method is successfully applied to pure and pharmaceutical dosage forms of Mianserin. The quantitative assessment of tolerable limits of other drugs not interfering are also studied.
I I KAZI ,T AMAN ,Z A KHAN ,I U KHAN ,
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