In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25±0.02 to 5.04±0.2 µM. On the other hand all the compounds didn’t show cytotoxic activity against other forms of human cancer cells.
Urooj Nazim, Silpa Narayanan, Mohsin Ali, Khalid Mohammed Khan, Basharat Ali, Jonathan Li, Zhe-Sheng Chen, Mansoor Ahmed and Dong-Hua Yang
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