In this study, a novel electrochemical sensor for the determination of ibuprofen (IBU) is developed by modifying a glassy carbon electrode (GCE) with a composite of graphene (GR) and polythiophene (PTh). The unique combination of graphene’s exceptional conductivity and surface area with the high electrochemical stability of polythiophene enhances the sensor’s performance for IBU detection. The GR/PTh composite is synthesized via fluid/fluid interfacial polymerization and characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), providing essential insights into the morphology and structure of the composite material. The electrochemical behavior of IBU is investigated through differential pulse voltammetry (DPV) and cyclic voltammetry (CV), with a detection limit of 1.24 μM observed for IBU. The sensor demonstrates excellent reproducibility, stability, and selectivity, successfully distinguishing IBU from other common interferences. Moreover, the GR/PTh/GCE sensor exhibits a linear response for IBU concentrations ranging from 10 to 80 μM, making it a promising tool for the rapid and sensitive detection of IBU in pharmaceutical formulations and biological samples. This work highlights the potential of graphene-based nanocomposites for the development of advanced electrochemical sensors, offering a new approach to pharmaceutical analysis.
Iram Yasmin, Muhammad Imran Kanjal, Uzma Sattar, Muhammad Wasim Afzal, Muhammad Irfan Ahamad, Rana Muhammad Zulqarnain, Lotfi Mouni
You can use below filter to find your desired issue