Four different prodrugs were prepared by linking various antibiotic drugs (Ampicillin, Amoxicillin, Ceftriaxone, and Cefotaxime) with 4-maleimidobenzoic (4-(2,5-dihydro-1H-pyrrol-1-yl)benzoic acid), which is firstly converted to 4-(2,5-dihydro-1H-pyrrol-1-yl)benzoyl chloride in the presence of SOCl2 to form four maleimide derivatives [5a-d]. These derivatives were characterized by FT-IR, 1H NMR, 13CNMR, and C.H.N.S. and then studied for their antibacterial activity against E. coli and S. aureus bacteria. As well as studied the anti-cancer activities and determined their potential to reduce cell viability in the human breast cancer cell line MCF7. The findings show that the substances created in this study have a promising activity profile in terms of slowing the growth of both cancer cells and the chosen bacteria.
Ammar Abdul-Hussein Awad, Mohammed Alaa Abdul Zahra and Osama Hameed Rasheed
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