S-AIylidene barbituric acids were obtained by the Perkin condensation between a series of aromatic aldehydes and the active methylene group of barbituric acid. Through Mannich con­devation of these barbituric acid derivatives with secodary amines and formaldehyde, twelve Mannich bases were prepared. Six of the final compounds were screened for their antiinflammatory activity and toxicity. Three compounds were found to inhibit inflamation by 20%-32% . 


R K SATSANGI ,S M M ZAIDI ,S S TIWARI ,