The fate of cravit was determined in 9 female volunteers following oral administration of 500 mg tablets The blood samples were collected at specified time interval. concordration of cravit in plasma was determined by microbiological assay, that wm 2.39 µg/mi having 1.75 SD and 75% CV values. The pharmacokinetic parameters were determined according to single compartment open model. The average absorption rate constant was 2-0 1/hr, while absorption half-life was 0.34 hours. Average C. and T. values wary 2.43 mg/l and 1.60 hours while volume of distribution was 171 1. From T. studies it is concluded that absorption is delayed due to non-fating. So cravit can be administered orally in the presence of food. The elimination half life and total body clearance values were 7.40 and 16.54 hours respectively while total area under the plasma drug level time curve was 30.2 h. mg/1. It is clear that elimination half-life is not affected by the presence or absence of food.
T FIRDOS ,R IQBAL ,W H SHAH ,
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