Differents methods used for the synthesis of nitriles are being compared with respect to the yields of the nitriles synthesized. It is observed that the method using tosylmethyliscoyanide to convert ketones to nitries although gives only moderate yields but is advantageous as it is a single step reaction. The cyanation using accetonitrile followed by reductive dehydration also gives an excellent yields of the nitrile and introduces two carbon atoms in one step. In alkylation of nitries, the best yields were obtained using lithium diiospopylamide as a base . to the best of our knowledge of the nitriles synthesized, 2-(1-naphthyl)propionitrile, 3-(2,4,6-trimethylphenyl)butyronitrile and 3-(2,4,6-trimethoxyphenyl)butyronitrile, have not been reported in the literature so far.
H DUDDECK ,N H RAMA ,S HAMEED ,
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