This work considers the optimization and characterization of metronidazole-calcium alginate nanoparticles (MET-AlgNPs) by an ionotropic gelation technique. The effect of the amount of sodium alginate (Alg), metronidazole, and calcium chloride (CaCl2) as the factors affecting drug loading efficiency (LE), particle size and potential of formulations were optimized and analyzed by using multiple regressions. These formulations were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), zeta size and potential, scanning electron microscope (SEM) and in vitro drug release studies. XRD, FTIR, and TGA analysis indicated the presence of drug in MET-AlgNPs nanocomposites. In vitro drug released from nanocomposites was carried out and showed that the release rate of MET from the MET-AlgNPs nanocomposites was very slow. These results indicate an extended release of the drug from its respective nanocomposites, and therefore these nanocomposites have good potential to be used as extended-release formulations of the drug.

Hazem Abdul Kader Sabbagh, ,Samer Hasan Hussein-Al-Ali, Zead Abudayeh, Rami AyoubQais Ibrahim Abdallah Abualassa and Nashwan Abdallah Nashwan