High performance liquid chromatographic method with electrochemical detection was used to quantitate levels of tryptophan (Trp) and its metabolite 5-hydroxy-indole-3-acetic acid (5-HIAA) levels in erythrocytes and leucocytes of 41 uremic patients. These patients were treated by maintenance hemodialysis (HD, n = 18) and continuous ambulatory peritoneal dialysis (CAPD, n = 25). The method of analysis is accurate, sensitive and reproducible. The results accumulated in uremic patients are statistically compared with age-matched healthy subjects (n = 21). The results demonstrate the abnormal intracellular distribution of Trp and 5-HIAA in uremic patients.
G A QURSHI ,S M BAIG ,M Y KHUHAWAR ,
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