Sixteen new quinazolinone derivatives have been synthesiled by the reaction of 2styryl-6, 8-disubstituted benzoxazjn.4-o~ with two different aromatic ambles (p-morpholino lIDiline and 2-aminopyridjne) or with two different hydruiclea (viz. iJonicotink: acid hydrazide and 2,4dinitrophenyl acetic acid hydrazide) in pyridine. The intermediate 2-styryl 6.lktiIubstituted benzo. xin-4-ones, were prepared by the reaction of cinnlmQyl chloride and 6.8-cliIUbstituted anthranlic acid in dry pyridine. Some of the synthesiled title compounds have been found to poaeIS lipificant anti-inflammatory activity against carrageenin-induced in1Iammation. An attempt hu also been made to establish a definite structure activity relationship. Further, in addition, the compounds were found to be mild central nervous system depreuaats and were quite non toxic. The structures of the unknown compounds were confirmed by elemental and spectral (LIt. cl P.M.L) analysis.
C SINGH ,V S MISRA ,R AGARWAL ,K C CHAUDHARY ,
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